Showing posts with label Cirrhosis. Show all posts
Showing posts with label Cirrhosis. Show all posts

Sunday, 1 February 2015

More Than Two Drinks Per Day Can Increase Your Risk of Stroke

According to a new study, drinking more than 2 alcoholic drinks each day in middle-age increases a person’s risk of stroke more than typical risk factors such as high blood pressure and diabetes.

Researchers used data gathered between 1967 and 2010 from 11,644 individuals from the Swedish Twin Registry to compare the effects of heavy drinking on risk of stroke. Heavy drinking was defined as 2 or more drinks per day and light drinking as less than 0.5 drinks per day.  

Results demonstrated that heavy drinking increased the risk of stroke by 34% in comparison to light drinking.  The heavy drinkers were also more likely to have a stroke 5 years earlier than their counterparts, regardless of genetics or other factors.  In addition, middle-aged heavy drinkers exhibited a risk of stroke comparable to individuals with high blood pressure and diabetes.  Moreover, the study found that almost 30% of participants had suffered a stroke and by age 75, blood pressure and diabetes were regarded as the main cause of stroke. 

“Among identical twin pairs, siblings who had a stroke drank more than their siblings who hadn't had a stroke, suggesting that mid-life drinking raises stroke risks regardless of genetics and early lifestyle.”

Not only does regular heavy drinking increase the risk of stroke, it also affects blood pressure and causes various health complications.  


Effects of Alcohol:

Drinking too much – on a single occasion or over time – can take a serious toll on your health.  Here’s how alcohol can affect your body:

Heart: Drinking a lot over a long time or too much on a single occasion can damage the heart, causing problems including:
  • Cardiomyopathy – Stretching and drooping of heart muscle
  • Arrhythmias – Irregular heart beat
  • Stroke
  • High blood pressure  
* Research also shows that drinking moderate amounts of alcohol may protect healthy adults from developing coronary heart disease.

Liver: Heavy drinking takes a toll on the liver, and can lead to a variety of problems and liver inflammations including:
  • Steatosis, or fatty liver
  • Alcoholic hepatitis
  • Fibrosis
  • Cirrhosis
Pancreas: Alcohol causes the pancreas to produce toxic substances that can eventually lead to pancreatitis, a dangerous inflammation and swelling of the blood vessels in the pancreas that prevents proper digestion. 

Cancer: Drinking too much alcohol can increase your risk of developing certain cancers, including cancers of the:
  • Mouth
  • Esophagus
  • Throat
  • Liver
  • Breast
Immune System: Drinking too much can weaken your immune system, making your body a much easier target for disease.  Chronic drinkers are more liable to contract diseases like pneumonia and tuberculosis than people who do not drink too much.  Drinking a lot on a single occasion slows your body’s ability to ward off infections – even up to 24 hours after getting drunk.

Brain: Alcohol interferes with the brain’s communication pathways, and can affect the way the brain looks and works. These disruptions can change mood and behavior, and make it harder to think clearly and move with coordination.  

People who have been drinking large amounts of alcohol for long periods of time run the risk of developing serious and persistent changes in the brain. Damage may be a result of the direct effects of alcohol on the brain or may result indirectly, from a poor general health status or from severe liver disease.

Up to 80 percent of alcoholics, however, have a deficiency in thiamine, and some of these people will go on to develop serious brain disorders such as Wernicke–Korsakoff syndrome (WKS).  WKS is a disease that consists of two separate syndromes, a short–lived and severe condition called Wernicke’s encephalopathy and a long–lasting and debilitating condition known as Korsakoff’s psychosis.

The symptoms of Wernicke’s encephalopathy include mental confusion, paralysis of the nerves that move the eyes (i.e., oculomotor disturbances), and difficulty with muscle coordination. For example, patients with Wernicke’s encephalopathy may be too confused to find their way out of a room or may not even be able to walk. 

Approximately 80 to 90 percent of alcoholics with Wernicke’s encephalopathy also develop Korsakoff’s psychosis, a chronic and debilitating syndrome characterized by persistent learning and memory problems. Patients with Korsakoff’s psychosis are forgetful and quickly frustrated and have difficulty with walking and coordination. Although these patients have problems remembering old information (i.e., retrograde amnesia), it is their difficulty in “laying down” new information (i.e., anterograde amnesia) that is the most striking. 

Heavy drinking in middle-age may increase stroke risk more than traditional factors
National Institute on Alcohol Abuse and Alcoholism

© www.mentalhealthblog.com

Saturday, 19 January 2013

Choline Supplements During Pregnancy May Prevent Schizophrenia


Research shows that the use of choline supplements during pregnancy may prevent schizophrenia.  Specifically, lower rates of physiological schizophrenic risk factors in infants 33 days old has been noted when the dietary supplement is given during the second and third trimesters of pregnancy and early infancy.

Robert Freedman, MD, professor and chairman of the Department of Psychiatry, University of Colorado School of Medicine and one of the study's authors states: "Basic research indicates that choline supplementation during pregnancy facilitates cognitive functioning in offspring. Our finding that it ameliorates some of the pathophysiology associated with risk for schizophrenia now requires longer-term follow-up to assess whether it decreases risk for the later development of illness as well."

Choline is a water-soluble essential nutrient, typically grouped within the B-complex vitamins. It can be found naturally in foods such as liver, muscle meats, fish, nuts and eggs.  According to the American Institute of Medicine, pregnant women require between 450 and 3500 milligrams of choline each day and 550 to 3500 milligrams while lactating.  Infants aged 0-6 months need a minimum daily dose of 125 milligrams of choline and 150 milligrams from 7-12 months of age.

“Choline is also being studied for potential benefits in liver disease, including chronic hepatitis and cirrhosis, depression, memory loss, Alzheimer's disease and dementia, and certain types of seizures.”

To test their theory, researchers observed infant responses to a clicking sound.  Typically, the brain responds fully to an initial click, however the response to a second click immediately following the first is inhibited.  This trait is often absent among schizophrenia patients and relates to poor sensory filtering and familial transmission of schizophrenia risk.  Researchers observed this effect among infants to represent the illness as schizophrenia does not normally appear until adolescence.

“Half the healthy pregnant women in this study took 3,600 milligrams of phosphatidylcholine each morning and 2,700 milligrams each evening; the other half took placebo. After delivery, their infants received 100 milligrams of phosphatidylcholine per day or placebo. Eighty-six percent of infants exposed to pre- and postnatal choline supplementation, compared to 43% of unexposed infants, inhibited the response to repeated sounds, as measured with EEG sensors placed on the baby's head during sleep.”

These results could not only assist in early detection of schizophrenia, but may even help in preventing the illness or developing more effective treatments.

Some examples of choline found in different food sources:

Type of Food
mg of choline
5 ounces (142 g) raw beef liver
473
Large hardboiled egg
113
Half a pound (227 g) cod fish
190
Half a pound of chicken
150
Quart of milk, 1% fat
173
A gram soy lecithin
30
100 grams of Soybeans dry
116
A pound (454 grams) of cauliflower
177
A pound of spinach
113
A cup of wheat germ
202
Two cups (0.47 liters) firm tofu
142
Two cups of cooked kidney beans
108
A cup of uncooked quinoa
119
A cup of uncooked amaranth
135
A grapefruit
19
Three cups (710 cc) cooked brown rice
54
A cup (146 g) of peanuts
77
A cup (143 g) of almonds
74

Choline Supplementation DuringPregnancy Presents a New Approach to Schizophrenia Prevention
Choline